Connexins 37 and 40 transduce purinergic signals mediating renal autoregulation.
@article{Takenaka2008Connexins3A, title={Connexins 37 and 40 transduce purinergic signals mediating renal autoregulation.}, author={Tsuneo Takenaka and Tsutomu Inoue and Yoshihiko Kanno and Hirokazu Okada and Caryl E. Hill and Hiromichi Suzuki}, journal={American journal of physiology. Regulatory, integrative and comparative physiology}, year={2008}, volume={294 1}, pages={ R1-11 } }
Our previous data indicated that various subtypes of connexin (Cx) were expressed in the juxtaglomerular apparatus. Experiments were performed to characterize the effects on renal autoregulation of specific mimetic peptides that inhibit these Cx subtypes in Wistar-Kyoto rats. Intrarenal infusion of (Cx37,43)GAP27 increased autoregulatory index of renal plasma flow (0.06 +/- 0.05 to 0.47 +/- 0.06, n = 6, P < 0.05) and glomerular filtration rate (GFR; 0.01 +/- 0.07 to 0.49 +/- 0.07, P < 0.05…
45 Citations
Direct assessment of tubuloglomerular feedback responsiveness in connexin 40-deficient mice.
- Biology, MedicineAmerican journal of physiology. Renal physiology
- 2013
The TGF response magnitude in superficial cortical nephrons is reduced by 30-50% in mice without Cx40, but that with the exception of a small number of nephron, residual TGF activity is maintained, perhaps by determining the kinetics of signal transmission.
Elucidating mechanisms underlying altered renal autoregulation in diabetes.
- Medicine, BiologyAmerican journal of physiology. Regulatory, integrative and comparative physiology
- 2012
The present data provide the first demonstration for a salt paradox in type 2 diabetes and implicate that in addition to Cx alterations, an enhanced proximal reabsorption attenuates TGF, underlying glomerular hyperfiltration and RAS activation.
Effect of ramipril on the regulation of the expression of connexins 40 and 43 in a rabbit model of arterial balloon injury.
- BiologyMolecular medicine reports
- 2012
The aim of this study was to determine whether Cx40 and Cx43 play different roles in the renin-angiotensin system (RAS) involved in the remodeling of GJs in VSMCs under pathological conditions.
ATP, P2 receptors and the renal microcirculation
- Biology, MedicinePurinergic Signalling
- 2009
Findings related to the role of P2 receptors in regulating renal microvascular function and the respective roles of ATP and adenosine in autoregulatory resistance adjustments are consolidated and areas of controversy are presented.
Connexins and the Kidney Connexin 45 is expressed in the juxtaglomerular apparatus and is involved in the regulation of renin secretion and blood pressure
- Biology
- 2008
The localization of Cx45 to the JGA and functional data from C x45fl/fl:Nestin-Cre mice suggest that Cx 45 is involved in the propagation of JGA vascular signals and in the regulation of renin release and blood pressure.
Renal autoregulation in health and disease.
- Biology, MedicinePhysiological reviews
- 2015
A combination of vascular and tubular mechanisms, novel to the kidney, provides for high autoregulatory efficiency that maintains RBF and GFR, stabilizes sodium excretion, and buffers transmission of RPP to sensitive glomerular capillaries, thereby protecting against hypertensive barotrauma.
Regulation of Renal Hemodyamics by Purinergic Receptors in Angiotensin II -Induced Hypertension
- Biology, Medicine
- 2012
Both, P1 and P2 receptors participate in the in the regulation of vascular tone and hemodynamics in the kidney microvasculature, and have an important role in the tubuloglomerular feedback mechanism.
Altered gap junctional communication and renal haemodynamics in Zucker fatty rat model of type 2 diabetes
- Biology, MedicineDiabetologia
- 2011
The findings indicate that ZDF rats have glomerular hyperfiltration with impaired autoregulation and an impairment of gap junctional communication in juxtaglomerular apparatus plays a role in altered renal autoreGulation in diabetes.
Contribution of renal purinergic receptors to renal vasoconstriction in angiotensin II-induced hypertensive rats.
- Biology, MedicineAmerican journal of physiology. Renal physiology
- 2011
There is an enhanced P2 receptor-mediated vasoconstriction of afferent and efferent arterioles in chronic Ang II-infused rats, which contributes to the increased renal vascular resistance observed in ANG II-dependent hypertension.
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