Connexin43 suppresses MFG-E8 while inducing contact growth inhibition of glioma cells.

@article{Goldberg2000Connexin43SM,
  title={Connexin43 suppresses MFG-E8 while inducing contact growth inhibition of glioma cells.},
  author={Gary S Goldberg and John F. Bechberger and Youichi Tajima and Mary Merritt and Yasufumi Omori and Mary Ann Gawinowicz and Ramaswamy Narayanan and Yi Tan and Yutaka Sanai and Hiroshi Yamasaki and Christian C. Naus and Hiroyuki Tsuda and Bruce J Nicholson},
  journal={Cancer research},
  year={2000},
  volume={60 21},
  pages={6018-26}
}
Gap junction expression has been reported to control the growth of a variety of transformed cells. We undertook parallel analysis of connexins Cx32 and Cx43 in glioma cells, which revealed potential mechanisms underlying this phenomenon and led to several novel findings. Cx43, but not Cx32, suppressed C6 glioma cell growth. Paradoxically, Cx32 transfection resulted in severalfold more dye transfer than Cx43. However, Cx43 transfectants shared endogenous metabolites more efficiently than Cx32… CONTINUE READING

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