Connexin43 and the Intercellular Signaling Network Regulating Skeletal Remodeling

@article{Moorer2017Connexin43AT,
  title={Connexin43 and the Intercellular Signaling Network Regulating Skeletal Remodeling},
  author={Megan C Moorer and Joseph P. Stains},
  journal={Current Osteoporosis Reports},
  year={2017},
  volume={15},
  pages={24-31}
}
Purpose of the ReviewThis review highlights recent developments into how intercellular communication through connexin43 facilitates bone modeling and remodeling.Recent FindingsConnexin43 is required for both skeletal development and maintenance, particularly in cortical bone, where it carries out multiple functions, including preventing osteoclastogenesis, restraining osteoprogenitor proliferation, promoting osteoblast differentiation, coordinating organized collagen matrix deposition, and… CONTINUE READING
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