Connexin43 Deficiency Causes Delayed Ossification, Craniofacial Abnormalities, and Osteoblast Dysfunction

@article{Lecanda2000Connexin43DC,
  title={Connexin43 Deficiency Causes Delayed Ossification, Craniofacial Abnormalities, and Osteoblast Dysfunction},
  author={Fernando Lecanda and Pamela M. Warlow and Sharmin Sheikh and Federico Furlan and Thomas Harry Steinberg and Roberto Civitelli},
  journal={The Journal of Cell Biology},
  year={2000},
  volume={151},
  pages={931 - 944}
}
Connexin(Cx)43 is the major gap junction protein present in osteoblasts. We have shown that overexpression of Cx45 in osteoblasts expressing endogenous Cx43 leads to decreased cell-cell communication (Koval, M., S.T. Geist, E.M. Westphale, A.E. Kemendy, R. Civitelli, E.C. Beyer, and T.H. Steinberg. 1995. J. Cell Biol. 130:987-995) and transcriptional downregulation of several osteoblastic differentiation markers (Lecanda, F., D.A. Towler, K. Ziambaras, S.-L. Cheng, M. Koval, T.H. Steinberg, and… CONTINUE READING

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References

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SHOWING 1-10 OF 39 REFERENCES

Gap Junction–mediated Cell–Cell Communication Modulates Mouse Neural Crest Migration

  • The Journal of cell biology
  • 1998
VIEW 11 EXCERPTS
HIGHLY INFLUENTIAL

Murine osteoclasts and spleen cell polykaryons are distinguished by mRNA phenotyping.

  • Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 1994
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Cyclic stretch enhances gap junctional communication between osteoblastic cells.

  • Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 1998
VIEW 2 EXCERPTS

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