Connexin40 regulates renin production and blood pressure.

  title={Connexin40 regulates renin production and blood pressure.},
  author={Nathalie Krattinger and Alessandro M Capponi and Lucia Mazzolai and J-F Aubert and Doroth{\'e}e Caille and Pascal Nicod and G{\'e}rard Waeber and Paolo Meda and J-A Haefliger},
  journal={Kidney international},
  volume={72 7},
Renin secretion is regulated by coordinated signaling between the various cells of the juxtaglomerular apparatus. The renin-secreting cells (RSC), which play a major role in the control of blood pressure, are coupled to each other and to endothelial cells by Connexin40 (Cx40)-containing channels. In this study, we show that Cx40 knockout (Cx40-/-) mice, but not their heterozygous littermates, are hypertensive due to the increase in the number of RSC, renin biosynthesis, and plasma renin… CONTINUE READING
Highly Influential
This paper has highly influenced 13 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
67 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 67 extracted citations

Similar Papers

Loading similar papers…