Connexin30 null and conditional connexin26 null mice display distinct pattern and time course of cellular degeneration in the cochlea.

@article{Sun2009Connexin30NA,
  title={Connexin30 null and conditional connexin26 null mice display distinct pattern and time course of cellular degeneration in the cochlea.},
  author={Yu Yo Sun and Wenxue Tang and Qing Chang and Yunfeng Wang and Wei-jia Kong and Xi Lin},
  journal={The Journal of comparative neurology},
  year={2009},
  volume={516 6},
  pages={569-79}
}
Mutations in connexin26 (Cx26) and Cx30 are the most common cause of nonsyndromic inherited deafness in humans. To understand the underlying molecular mechanisms, we investigated the pattern and time course of cellular degeneration in the cochlea of conditional Cx26 (cCx26) null and Cx30 null mice. In cCx26 null mice, initial degeneration was observed around postnatal day 14 in outer hair cells (OHCs) and supporting cells surrounding the OHCs. All cells in the middle turn organ of Corti were… CONTINUE READING
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