Connexin26 is responsible for anionic molecule permeability in the cochlea for intercellular signalling and metabolic communications.

@article{Zhao2005Connexin26IR,
  title={Connexin26 is responsible for anionic molecule permeability in the cochlea for intercellular signalling and metabolic communications.},
  author={H Zhao},
  journal={The European journal of neuroscience},
  year={2005},
  volume={21 7},
  pages={1859-68}
}
  • H Zhao
  • Published 2005 in The European journal of neuroscience
Abstract A gap junction is composed of two hemichannels and possesses a relatively large pore size ( approximately 10-15 A), allowing passage of ions and molecules up to 1 kDa. Here, we report that connexin hemichannels and gap junctions in the guinea pig cochlea had significant charge selectivity among permeating molecules. In coincubation with anionic and cationic fluorescent dyes, hemichannel permeability in isolated cochlear supporting cells showed significant charge selectivity; 31% of… CONTINUE READING