Connexin-specific cell-to-cell transfer of short interfering RNA by gap junctions.

  title={Connexin-specific cell-to-cell transfer of short interfering RNA by gap junctions.},
  author={Virginijus Valiunas and Yaroslava Y. Polosina and Heather B Miller and Irina A. Potapova and Laima Valiuniene and Sergey Doronin and Richard T. Mathias and Richard B. Robinson and Michael R. Rosen and Ira S. Cohen and Peter R. Brink},
  journal={The Journal of physiology},
  volume={568 Pt 2},
The purpose of this study was to determine whether oligonucleotides the size of siRNA are permeable to gap junctions and whether a specific siRNA for DNA polymerase beta (pol beta) can move from one cell to another via gap junctions, thus allowing one cell to inhibit gene expression in another cell directly. To test this hypothesis, fluorescently labelled oligonucleotides (morpholinos) 12, 16 and 24 nucleotides in length were synthesized and introduced into one cell of a pair using a patch… CONTINUE READING


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The prospect of silencing disease using RNA interference

  • P Shankar, W Manjunath, J Liebermann
  • JAMA
  • 2005
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