Connexin mimetic peptides reversibly inhibit Ca(2+) signaling through gap junctions in airway cells.

  title={Connexin mimetic peptides reversibly inhibit Ca(2+) signaling through gap junctions in airway cells.},
  author={Scott A. Boitano and William Howard Evans},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  volume={279 4},
  • S. BoitanoW. H. Evans
  • Published 1 October 2000
  • Biology
  • American journal of physiology. Lung cellular and molecular physiology
The effect of peptides with sequences derived from connexins, the constituent proteins of gap junctions, on mechanically stimulated intercellular Ca(2+) signaling in tracheal airway epithelial cells was studied. Three peptides with sequences corresponding to connexin extracellular loop regions reversibly restricted propagation of Ca(2+) waves to neighboring cells. Recovery of communication began within 10 min of removal of the peptides, with inhibition totally reversed by 20-40 min. The… 

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