Connexin-mediated cardiac impulse propagation: connexin 30.2 slows atrioventricular conduction in mouse heart.

@article{Kreuzberg2006ConnexinmediatedCI,
  title={Connexin-mediated cardiac impulse propagation: connexin 30.2 slows atrioventricular conduction in mouse heart.},
  author={Maria M Kreuzberg and Klaus Willecke and Feliksas F. Bukauskas},
  journal={Trends in cardiovascular medicine},
  year={2006},
  volume={16 8},
  pages={266-72}
}
In mouse heart, four connexins (Cxs), Cx30.2, Cx40, Cx43, and Cx45, form gap junction (GJ) channels for electric and metabolic cell-to-cell signaling. Extent and pattern of Cx isoform expression together with cytoarchitecture and excitability of cells determine the velocity of excitation spread in different regions of the heart. In the SA node, cell-cell coupling is mediated by Cx30.2 and Cx45, which form low-conductance (approximately 9 and 32 pS, respectively) GJ channels. In contrast, the… CONTINUE READING

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