Connexin lateralization during Coronary Artery Bypass Graft (CABG) operation: a target for the antiarrhythmic effect of colchicine in the prevention of post-operative atrial fibrillation

@inproceedings{Saenen2013ConnexinLD,
  title={Connexin lateralization during Coronary Artery Bypass Graft (CABG) operation: a target for the antiarrhythmic effect of colchicine in the prevention of post-operative atrial fibrillation},
  author={Johan Saenen and Philippe Vanduynhoven and Isabel Pintelon and H. Miljoen and J. P. Timmermans and Steven Laga and Wim Vergauwen and Inez E. R. Rodrigus and Chris J. Vrints},
  year={2013}
}
Purpose: Post-operative AF (POAF) is a common complication that increases morbidity following CABG. Although statins, propafenone and nitroprusside have reduced POAF none of the studies established a clear link between the pathogenesis of POAF and their favorable effects. Likely, the lack of a mechanistic rationale has impeded these compounds from becoming routine peri-operative practice. Recently the COPPS POAF trial showed that colchicine reduced POAF by almost 50% which was ascribed to its… CONTINUE READING