Connexin channels provide a target to manipulate brain endothelial calcium dynamics and blood-brain barrier permeability.

@article{Bock2011ConnexinCP,
  title={Connexin channels provide a target to manipulate brain endothelial calcium dynamics and blood-brain barrier permeability.},
  author={Marijke De Bock and Maxime Culot and Nan Wang and M{\'e}lissa Bol and Elke Decrock and Elke De Vuyst and Anaelle da Costa and Ine Dauwe and Mathieu Vinken and Alexander M. Simon and Vera Rogiers and Gaspard De Ley and W. H. Evans and Geert Bultynck and Genevi{\`e}ve Dupont and Rom{\'e}o Cecchelli and Luc Leybaert},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2011},
  volume={31 9},
  pages={1942-57}
}
The cytoplasmic Ca(2+) concentration ([Ca(2+)](i)) is an important factor determining the functional state of blood-brain barrier (BBB) endothelial cells but little is known on the effect of dynamic [Ca(2+)](i) changes on BBB function. We applied different agonists that trigger [Ca(2+)](i) oscillations and determined the involvement of connexin channels and subsequent effects on endothelial permeability in immortalized and primary brain endothelial cells. The inflammatory peptide bradykinin (BK… CONTINUE READING
36 Citations
55 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 36 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 55 references

Similar Papers

Loading similar papers…