Connexin and pannexin signaling in gastrointestinal and liver disease.

  title={Connexin and pannexin signaling in gastrointestinal and liver disease.},
  author={Micha{\"e}l Maes and Sara Crespo Yanguas and Joost Willebrords and Bruno Cogliati and Mathieu Vinken},
  journal={Translational research : the journal of laboratory and clinical medicine},
  volume={166 4},
Gap junctions, which mediate intercellular communication, are key players in digestive homeostasis. They are also frequently involved in gastrointestinal and liver pathology. This equally holds true for connexin (Cx) hemichannels, the structural precursors of gap junctions, and pannexin (Panx) channels, Cx-like proteins assembled in a hemichannel configuration. Both Cx hemichannels and Panx channels facilitate extracellular communication and drive a number of deteriorative processes, such as… CONTINUE READING


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