Connexin Hemichannel Blockade Is Neuroprotective after Asphyxia in Preterm Fetal Sheep

@inproceedings{Davidson2014ConnexinHB,
  title={Connexin Hemichannel Blockade Is Neuroprotective after Asphyxia in Preterm Fetal Sheep},
  author={Joanne O Davidson and Paul P. Drury and Colin Richard Green and Louise F. B. Nicholson and Laura Bennet and Alistair J. Gunn},
  booktitle={PloS one},
  year={2014}
}
Asphyxia around the time of preterm birth is associated with neurodevelopmental disability. In this study, we tested the hypothesis that blockade of connexin hemichannels would improve recovery of brain activity and reduce cell loss after asphyxia in preterm fetal sheep. Asphyxia was induced by 25 min of complete umbilical cord occlusion in preterm fetal sheep (103-104 d gestational age). Connexin hemichannels were blocked by intracerebroventricular infusion of mimetic peptide starting 90 min… CONTINUE READING

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