Connexin 43 mediates spread of Ca2+-dependent proinflammatory responses in lung capillaries.

@article{Parthasarathi2006Connexin4M,
  title={Connexin 43 mediates spread of Ca2+-dependent proinflammatory responses in lung capillaries.},
  author={Kaushik Parthasarathi and Hideo Ichimura and Eiji Monma and Jens Lindert and Syed Bilal Quadri and Andrew C. Issekutz and Jayeetha Bhattacharya},
  journal={The Journal of clinical investigation},
  year={2006},
  volume={116 8},
  pages={
          2193-200
        }
}
Acute lung injury (ALI), which is associated with a mortality of 30-40%, is attributable to inflammation that develops rapidly across the lung's vast vascular surface, involving an entire lung or even both lungs. No specific mechanism explains this extensive inflammatory spread, probably because of the lack of approaches for detecting signal conduction in lung capillaries. Here, we addressed this question by applying the photolytic uncaging approach to induce focal increases in Ca2+ levels in… CONTINUE READING

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