Connexin 43 is required for the anti-apoptotic effect of bisphosphonates on osteocytes and osteoblasts in vivo.

@article{Plotkin2008Connexin4I,
  title={Connexin 43 is required for the anti-apoptotic effect of bisphosphonates on osteocytes and osteoblasts in vivo.},
  author={Lilian Irene Plotkin and Virginia Lezcano and Jeff D. Thostenson and Robert S. Weinstein and Stavros C Manolagas and Teresita M. Bellido},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2008},
  volume={23 11},
  pages={1712-21}
}
Connexin (Cx)43 is required for inhibition of osteocyte and osteoblast apoptosis by bisphosphonates in vitro. Herein, we evaluated its requirement for the in vivo actions of bisphosphonates using mice in which Cx43 was deleted specifically from osteocytes and osteoblasts (Cx43(DeltaOb-Ot/-) mice). Effective removal of Cx43 was confirmed by the presence of the deleted form of the gene and by reduced mRNA and protein expression in osteoblastic cells and bones obtained from Cx43(DeltaOb-Ot/-) mice… CONTINUE READING

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