Connexin 43 hemi channels mediate Ca2+-regulated transmembrane NAD+ fluxes in intact cells.

@article{Bruzzone2001Connexin4H,
  title={Connexin 43 hemi channels mediate Ca2+-regulated transmembrane NAD+ fluxes in intact cells.},
  author={Santina Bruzzone and L. Guida and Elena Zocchi and Luisa Franco and A DeFlora},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2001},
  volume={15 1},
  pages={10-12}
}
A previously unrecognized passive transport for pyridine dinucleotides has been described recently in the plasmamembrane of several mammalian cells. Despite elucidation of some functional and kinetic properties of this transport system, it is still undefined at the molecular level. Therefore, we have addressed the molecular characterization of the NAD+ transporter and identified it as connexin 43 (Cx43). This is a structural component of hexameric hemichannels that, when juxtaposed on adjacent… CONTINUE READING

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