Connexin 43 and ERK regulate tension-induced signal transduction in human periodontal ligament fibroblasts.

@article{Li2015Connexin4A,
  title={Connexin 43 and ERK regulate tension-induced signal transduction in human periodontal ligament fibroblasts.},
  author={Shengnan Li and Huajing Zhang and Shuna Li and Yanqi Yang and Bo Huo and Ding Zhang},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  year={2015},
  volume={33 7},
  pages={1008-14}
}
Periodontal ligament (PDL) fibroblasts play an important role in preserving periodontal homeostasis and transmitting mechanical signals to alveolar bone. Connexin 43 (Cx43), a gap junction protein, is essential for bone homeostasis and regulates bone remodeling. However, the function of Cx43 in human PDL fibroblast-regulated bone remodeling has not yet been elucidated. In this study, human PDL fibroblasts were exposed to cyclic mechanical tension with a maximum 5% elongation for different… CONTINUE READING
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