Connexin 43 C‐terminus directly inhibits the hyperphosphorylation of Akt/ERK through protein–protein interactions in glioblastoma

@inproceedings{Kuang2018Connexin4C,
  title={Connexin 43 C‐terminus directly inhibits the hyperphosphorylation of Akt/ERK through protein–protein interactions in glioblastoma},
  author={Jing-Ya Kuang and Yufeng Guo and Ying Chen and Jun Rong Wang and Jiang-jie Duan and Xiao-Li He and Lin Li and Shi-Cang Yu and Xiu-Wu Bian},
  booktitle={Cancer science},
  year={2018}
}
Although the deregulation of epidermal growth factor receptor (EGFR) is one of the most common molecular mechanisms of glioblastoma (GBM) pathogenesis, the efficacy of anti-EGFR therapy is limited. Additionally, response to anti-EGFR therapy is not solely dependent on EGFR expression and is more promising in patients with reduced activity of EGFR downstream signaling pathways. Thus, there is considerable interest in identifying the compensatory regulatory factors of the EGFR signaling pathway… CONTINUE READING
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