Connexin 43 Astrocytopathy Linked to Rapidly Progressive Multiple Sclerosis and Neuromyelitis Optica

@inproceedings{Masaki2013Connexin4A,
  title={Connexin 43 Astrocytopathy Linked to Rapidly Progressive Multiple Sclerosis and Neuromyelitis Optica},
  author={Katsuhisa Masaki and S O Suzuki and Takuya Matsushita and Takeshi Matsuoka and Shihoko Imamura and Ryo Yamasaki and Makiko Suzuki and Toshihiko Suenaga and Toru Iwaki and Jun-ichi Kira},
  booktitle={PloS one},
  year={2013}
}
BACKGROUND Multiple sclerosis (MS) and neuromyelitis optica (NMO) occasionally have an extremely aggressive and debilitating disease course; however, its molecular basis is unknown. This study aimed to determine a relationship between connexin (Cx) pathology and disease aggressiveness in Asian patients with MS and NMO. METHODS/PRINCIPAL FINDINGS Samples included 11 autopsied cases with NMO and NMO spectrum disorder (NMOSD), six with MS, and 20 with other neurological diseases (OND). Methods… CONTINUE READING

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