Connexin 32 and 43 gap junctions differentially modulate tenocyte response to cyclic mechanical load.

@article{Waggett2006Connexin3A,
  title={Connexin 32 and 43 gap junctions differentially modulate tenocyte response to cyclic mechanical load.},
  author={Andrew D Waggett and Mike Benjamin and James R. Ralphs},
  journal={European journal of cell biology},
  year={2006},
  volume={85 11},
  pages={1145-54}
}
Gap junctions allow rapid exchange of ions and small metabolites between cells. They can occur between connective tissue cells, and in tendons there are two prominent types, composed of connexin 32 or 43. These form distinct networks - tenocyte rows are linked by both longitudinally, but only by connexin 43 laterally. We hypothesised that the junctions had different roles in cell response to mechanical loading, and measured the effects of inhibitors of gap junction function on secretion of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 39 extracted citations

The pain of tendinopathy: physiological or pathophysiological?

Sports medicine • 2014
View 9 Excerpts
Highly Influenced

The Effect of Mechanical Stimuli on Healing Achilles Tendons in Rats

Emma Malis
2009
View 3 Excerpts
Highly Influenced

Key developments that impacted the field of mechanobiology and mechanotransduction.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society • 2018

Similar Papers

Loading similar papers…