Connexin 30 sets synaptic strength by controlling astroglial synapse invasion

  title={Connexin 30 sets synaptic strength by controlling astroglial synapse invasion},
  author={Ulrike Pannasch and Dominik Freche and Glenn Dall{\'e}rac and Gr{\'e}gory Gh{\'e}zali and Carole Escartin and Pascal Ezan and Martine Cohen-Salmon and Karim Benchenane and Ver{\'o}nica Abudara and Amandine Dufour and Joachim H. R. L{\"u}bke and Nicole D{\'e}glon and Graham Knott and David Holcman and Nathalie Rouach},
  journal={Nature Neuroscience},
Astrocytes play active roles in brain physiology by dynamic interactions with neurons. Connexin 30, one of the two main astroglial gap-junction subunits, is thought to be involved in behavioral and basic cognitive processes. However, the underlying cellular and molecular mechanisms are unknown. We show here in mice that connexin 30 controls hippocampal excitatory synaptic transmission through modulation of astroglial glutamate transport, which directly alters synaptic glutamate levels… CONTINUE READING
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