Connexin 30 downregulates Insulin-like growth factor receptor-1, abolishes Erk and potentiates effects of an IGF-R inhibitor in a glioma cell line.

@article{Arun2016Connexin3D,
  title={Connexin 30 downregulates Insulin-like growth factor receptor-1, abolishes Erk and potentiates effects of an IGF-R inhibitor in a glioma cell line.},
  author={Sankaradoss Arun and Arambakkam Janardhanam Vanisree and Shantha Ravisankar},
  journal={Brain research},
  year={2016},
  volume={1643},
  pages={80-90}
}
Connexins (Cx) play a crucial role in cell communication though regulation of cell growth and proliferation. In recent decades, both suppressive and enhancing roles of gap junction proteins in malignancy have been proposed, though mechanisms remain unclear. We intend to evaluate the impact of Cx30 on dysregulated growth of glioma owing to an aberrant expression of Insulin-like growth factor-1 receptor (IGF-1R). The study also examined whether Cx30 expression influenced sensitivity of glioma… CONTINUE READING