Connexin 26 regulates epidermal barrier and wound remodeling and promotes psoriasiform response.

@article{Djalilian2006Connexin2R,
  title={Connexin 26 regulates epidermal barrier and wound remodeling and promotes psoriasiform response.},
  author={Ali R Djalilian and David M. McGaughey and Satyakam Patel and Eun Young Seo and Chenghua Yang and Jun Cheng and Melanija Tomi{\'c} and Satrajit Sinha and Akemi Ishida-Yamamoto and Julia A Segre},
  journal={The Journal of clinical investigation},
  year={2006},
  volume={116 5},
  pages={1243-53}
}
Inflammatory skin disorders result in significant epidermal changes, including keratinocyte hyperproliferation, incomplete differentiation, and impaired barrier. Here we test whether, conversely, an impaired epidermal barrier can promote an inflammatory response. Mice lacking the transcription factor Kruppel-like factor 4 (Klf4) have a severe defect in epidermal barrier acquisition. Transcription profiling of Klf4(-/-) newborn skin revealed similar changes in gene expression to involved… CONTINUE READING

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