Connectomes across development reveal principles of brain maturation.

@article{Witvliet2021ConnectomesAD,
  title={Connectomes across development reveal principles of brain maturation.},
  author={Daniel Witvliet and Ben Mulcahy and James K Mitchell and Yaron Meirovitch and Daniel R. Berger and Yuelong Wu and Yufang Liu and Wan Xian Koh and Rajeev Parvathala and Douglas Holmyard and Richard Schalek and Nir Shavit and Andrew D. Chisholm and Jeff William Lichtman and Aravinthan D. T. Samuel and Mei Zhen},
  journal={Nature},
  year={2021}
}
An animal's nervous system changes as its body grows from birth to adulthood and its behaviours mature1-8. The form and extent of circuit remodelling across the connectome is unknown3,9-15. Here we used serial-section electron microscopy to reconstruct the full brain of eight isogenic Caenorhabditis elegans individuals across postnatal stages to investigate how it changes with age. The overall geometry of the brain is preserved from birth to adulthood, but substantial changes in chemical… 
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