Connectivity-based segmentation of the striatum in Huntington's disease: Vulnerability of motor pathways

@article{Bohanna2011ConnectivitybasedSO,
  title={Connectivity-based segmentation of the striatum in Huntington's disease: Vulnerability of motor pathways},
  author={India Bohanna and Nellie Georgiou-Karistianis and Gary F. Egan},
  journal={Neurobiology of Disease},
  year={2011},
  volume={42},
  pages={475-481}
}
The striatum, the primary site of degeneration in Huntington's disease (HD), connects to the cerebral cortex via topographically organized circuits subserving unique motor, associative and limbic functions. Currently, it is not known whether all cortico-striatal circuits are equally affected in HD. We aimed to study the selective vulnerability of individual cortico-striatal circuits within the striatum in HD, and hypothesized that motor cortico-striatal pathways would be most affected… CONTINUE READING
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