Connective tissue growth factor mediates TGF-β1-induced low-grade serous ovarian tumor cell apoptosis.

@article{Cheng2017ConnectiveTG,
  title={Connective tissue growth factor mediates TGF-β1-induced low-grade serous ovarian tumor cell apoptosis.},
  author={Jung-Chien Cheng and Hsun-Ming Chang and Peter C K Leung},
  journal={Oncotarget},
  year={2017},
  volume={8 49},
  pages={
          85224-85233
        }
}
Ovarian low-grade serous carcinoma (LGSC) is a rare disease and is now considered to be a distinct entity from high-grade serous carcinoma (HGSC), which is the most common and malignant form of epithelial ovarian cancer. Connective tissue growth factor (CTGF) is a secreted matricellular protein that has been shown to modulate many biological functions by interacting with multiple molecules in the microenvironment. Increasing evidence indicates that aberrant expression of CTGF is associated with… CONTINUE READING