Connective tissue growth factor mediates high glucose effects on matrix degradation through tissue inhibitor of matrix metalloproteinase type 1: implications for diabetic nephropathy.

@article{Mclennan2004ConnectiveTG,
  title={Connective tissue growth factor mediates high glucose effects on matrix degradation through tissue inhibitor of matrix metalloproteinase type 1: implications for diabetic nephropathy.},
  author={Susan V. Mclennan and Xiaoqi Wang and Vanessa de Souza Moreno and Dennis Koon-See Yue and Stephen Morris Twigg},
  journal={Endocrinology},
  year={2004},
  volume={145 12},
  pages={5646-55}
}
High glucose concentration inhibits matrix degradation and affects the activities of the enzymes responsible, the matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs). Connective tissue growth factor (CTGF) expression is increased in diabetic nephropathy and is a downstream mediator of TGF-beta actions. However, whether CTGF regulates matrix degradation and the mechanism of effect in diabetes has not been reported. Human mesangial cells were cultured in media containing 5 or 25… CONTINUE READING

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