Connective tissue growth factor is secreted through the Golgi and is degraded in the endosome.

@article{Chen2001ConnectiveTG,
  title={Connective tissue growth factor is secreted through the Golgi and is degraded in the endosome.},
  author={Youjun Chen and Patricia Segarini and F Raoufi and Douglass Bradham and Andrew Leask},
  journal={Experimental cell research},
  year={2001},
  volume={271 1},
  pages={109-17}
}
Connective tissue growth factor (CTGF) is a cysteine-rich heparin-binding polypeptide that promotes proliferation, collagen synthesis, and chemotaxis in mesanchymal cells. When coinjected subcutaneously with transforming growth factor beta (TGFbeta), CTGF promotes sustained fibrosis in rats. However, little is known about the cell biology and structure/functional relationship of CTGF. In particular, no detailed characterization of the subcellular localization of CTGF has occurred, nor have… CONTINUE READING

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