Connective tissue growth factor inhibits metastasis and acts as an independent prognostic marker in colorectal cancer.

@article{Lin2005ConnectiveTG,
  title={Connective tissue growth factor inhibits metastasis and acts as an independent prognostic marker in colorectal cancer.},
  author={Been-Ren Lin and Cheng-Chi Chang and Ting-Fang Che and Szu-Ta Chen and Robert Jeen-Chen Chen and Ching-Yao Yang and Yung‐Ming Jeng and Jin-Tung Liang and Po-Huang Lee and King-Jen Chang and Yat Pang Chau and Ming Liang Kuo},
  journal={Gastroenterology},
  year={2005},
  volume={128 1},
  pages={
          9-23
        }
}
BACKGROUND & AIMS Connective tissue growth factor (CTGF) has been shown to be implicated in tumor development and progression. The aim of this study was to investigate the role of CTGF in progression of colorectal cancer (CRC). METHODS Immunohistochemical staining of specimens from 119 patients with CRC was performed. Liposome-mediated transfection was used to introduce a CTGF expression vector into CRC cell lines. Transfectants were tested in invasive ability and experimental hepatic… 
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114 Citations

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Citation Type

Connective Tissue Growth Factor Acts as a Therapeutic Agent and Predictor for Peritoneal Carcinomatosis of Colorectal Cancer
TLDR
Investigation of colorectal cancer patient specimens revealed an inverse correlation between CTGF expression and prevalence of PC, and lower CTGF level in CRC patients was associated with higher peritoneal recurrence rate after surgery.
Inhibition of connective tissue growth factor (CTGF/CCN2) in gallbladder cancer cells leads to decreased growth in vitro
TLDR
The results suggest that high expression of this protein in gallbladder cancer may confer a growth advantage for neoplastic cells.
Connective tissue growth factor inhibits gastric cancer peritoneal metastasis by blocking integrin α3β1-dependent adhesion
TLDR
The results suggested that gastric cancer peritoneal metastasis is mediated through integrin α3β1 binding to laminin, and CTGF effectively blocks the interaction by binding to integrinα3 β1, thus demonstrating the therapeutic potential of recombinant CTGF in Gastric cancer patients.
Downregulation of connective tissue growth factor inhibits the growth and invasion of gastric cancer cells and attenuates peritoneal dissemination
TLDR
It is suggested that CTGF plays an important role in cell growth and invasion in human gastric cancer and it appears to be a potential prognostic marker for patients with Gastric cancer.
Connective tissue growth factor modulates oral squamous cell carcinoma invasion by activating a miR-504/FOXP1 signalling
TLDR
A novel signal pathway involving the regulation of miRNA machinery by a secreted cytokine, which will be beneficial for developing therapeutic strategy against advanced OSCC is discovered.
Connective tissue growth factor in tumor pathogenesis
TLDR
Key roles for connective tissue growth factor (CTGF/CCN2) are demonstrated in the wound repair process where it promotes myofibroblast differentiation and angiogenesis and the presence of CTGF in other endocrine tumors indicates a role in the progression of well-differentiated tumors.
Connective tissue growth factor enhances the migration of gastric cancer through downregulation of E‐cadherin via the NF‐κB pathway
TLDR
Existence of CTGF was significantly upregulated in clinical tissue samples of gastric carcinoma (GC) samples and CTGF downregulated the expression of E‐cadherin through activation of the nuclear factor‐κappa B (NF‐κB) pathway, demonstrating CTGF could modulate the NF‐kkappaB pathway and perhaps be a promising therapeutic target for gastric cancer invasion and metastasis.
Suppression of Cell Proliferation and Signaling Transduction by Connective Tissue Growth Factor in Non–Small Cell Lung Cancer Cells
TLDR
The data suggest that CTGF may behave as a secreted tumor suppressor protein in the normal lung, and its expression is suppressed in many NSCLCs.
CTGF is overexpressed in papillary thyroid carcinoma and promotes the growth of papillary thyroid cancer cells
TLDR
It is found that CTGF expression level was elevated in primary papillary thyroid carcinoma (PTC) samples and correlated with clinical features, such as metastasis, tumor size, and clinical stage.
Connective tissue growth factor-specific monoclonal antibody therapy inhibits pancreatic tumor growth and metastasis.
TLDR
These studies implicate CTGF as a new target in pancreatic cancer and suggest that inhibition of CTGF with a human monoclonal antibody may control primary and metastatic tumor growth.
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References

SHOWING 1-10 OF 66 REFERENCES
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TLDR
Lower expression of CTGF in lung cancer specimens was statistically significantly associated with the risk of more advanced-stage disease, lymph node metastasis, and shorter survival.
Connective Tissue Growth Factor Gene Expression Alters Tumor Progression in Esophageal Cancer
TLDR
CTGF, a downstream effector of TGF-b action, differentially influences the composition of tumor microenvironment and distinct cell-matrix interactions in the two histological types of esophageal carcinoma, resulting in differences in tumor progression and patient survival.
Expression and differential regulation of connective tissue growth factor in pancreatic cancer cells
TLDR
In situ hybridization and the nude mouse experiments revealed that in pancreatic cancer tissues, fibroblasts are the predominant site of CTGF transcription, whereas the tumor cells appear to contribute to a lesser extent.
Neoplastic cells and proliferating endothelial cells express connective tissue growth factor (CTGF) in glioblastoma
TLDR
It is suggested that CTGF may have the potential to stimulate angiogenesis in glioblastoma and function as an angiogenic factor in the process of tumor growth.
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TLDR
VEGF is associated with the progression, invasion and metastasis of colorectal cancer, and overexpression of VEGF mRNA in the primary tumour is assumed to be closely correlated with poor prognosis in coloreCTal cancer patients.
Suppressive effect of overexpressed connective tissue growth factor on tumor cell growth in a human oral squamous cell carcinoma-derived cell line.
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β-Catenin Regulates the Expression of the Matrix Metalloproteinase-7 in Human Colorectal Cancer
The expression of p185(HER-2/neu) correlates with the stage of disease and survival in colorectal cancer.
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TLDR
VEGF is identified as a novel target of the Wnt pathway in early colonic neoplasia and served to underscore the importance of angiogenesis in premalignant disease.
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