Connective tissue growth factor increased by hypoxia may initiate angiogenesis in collaboration with matrix metalloproteinases.

@article{Kondo2002ConnectiveTG,
  title={Connective tissue growth factor increased by hypoxia may initiate angiogenesis in collaboration with matrix metalloproteinases.},
  author={Seiji Kondo and Satoshi Kubota and Tsuyoshi Shimo and Takashi Nishida and Gen Yosimichi and Takanori Eguchi and Toshio Sugahara and Masaharu Takigawa},
  journal={Carcinogenesis},
  year={2002},
  volume={23 5},
  pages={769-76}
}
Connective tissue growth factor (CTGF) is known to be a potent angiogenic factor. Here we investigated how CTGF and matrix metalloproteinases (MMPs) are involved in the early stage of hypoxia-induced angiogenesis using human breast cancer cell line, MDA231, and vascular endothelial cells. Hypoxic stimulation (5% O(2)) of MDA231 cells increased their steady-state level of ctgf mRNA by approximately 2-fold within 1.5 h, and the levels remained at a plateau up to 6 h, and then decreased by 12 h as… CONTINUE READING

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