Connective tissue growth factor gene expression and decline in renal function in lupus nephritis.

@article{Tachaudomdach2012ConnectiveTG,
  title={Connective tissue growth factor gene expression and decline in renal function in lupus nephritis.},
  author={Chiraporn Tachaudomdach and Surasak Kantachuvesiri and Siribha Changsirikulchai and Surangkana Wimolluck and Koset Pinpradap and Chagriya Kitiyakara},
  journal={Experimental and therapeutic medicine},
  year={2012},
  volume={3 4},
  pages={713-718}
}
In lupus nephritis (LN), kidney inflammation may be followed by fibrosis and progressive decline in function. Transforming growth factor (TGF)-β is a notable mediator of fibrosis, but it has other beneficial roles, thus indicating a need for alternate therapeutic targets for inhibition of fibrosis. Connective tissue growth factor (CTGF) acts as a downstream mediator of TGF-β in promoting fibrosis, without mediating the immunosuppressive effects of TGF-β. Animal studies show that CTGF may have… CONTINUE READING