Connective tissue growth factor expressed in tubular epithelium plays a pivotal role in renal fibrogenesis.

@article{Okada2005ConnectiveTG,
  title={Connective tissue growth factor expressed in tubular epithelium plays a pivotal role in renal fibrogenesis.},
  author={Hirokazu Okada and Tomohiro Kikuta and Tatsuya Kobayashi and Tsutomu Inoue and Yoshihiko Kanno and Masaharu Takigawa and Takeshi Sugaya and Jeffrey B. Kopp and Hiromichi Suzuki},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2005},
  volume={16 1},
  pages={133-43}
}
Connective tissue growth factor (CTGF) is one of the candidate factors that are thought to mediate the downstream profibrotic action of TGF-beta. However, its precise role in renal interstitial fibrogenesis has not yet been clarified. It was demonstrated previously that CTGF was expressed in tubular epithelial cells that had been engulfed by interstitial fibrosis in the remnant kidney of the subtotal nephrectomy (SNx) model. In the present study, co-cultures of tubular epithelial cells (mProx24… CONTINUE READING
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