Connective tissue growth factor causes glaucoma by modifying the actin cytoskeleton of the trabecular meshwork.

Abstract

The most critical risk factor for optic nerve damage in cases of primary open-angle glaucoma (POAG) is an increased intraocular pressure (IOP) caused by a resistance to aqueous humor outflow in the trabecular meshwork (TM). The molecular pathogenesis of this increase in outflow resistance in POAG has not yet been identified, but it may involve transforming… (More)
DOI: 10.1016/j.ajpath.2012.02.030

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