Connective tissue growth factor binds vascular endothelial growth factor (VEGF) and inhibits VEGF‐induced angiogenesis

@article{Inoki2002ConnectiveTG,
  title={Connective tissue growth factor binds vascular endothelial growth factor (VEGF) and inhibits VEGF‐induced angiogenesis},
  author={Isao Inoki and Takayuki Shiomi and Gakuji Hashimoto and Hiroyuki Enomoto and Hiroyuki Nakamura and Ken-ichi Makino and Eiji Ikeda and Shigeo Takata and Ken-ichi Kobayashi and Yasunori Okada},
  journal={The FASEB Journal},
  year={2002},
  volume={16}
}
Vascular endothelial growth factor (VEGF) is a strong angiogenic mitogen and plays important roles in angiogenesis under various pathophysiological conditions. The in vivo angiogenic activity of secreted VEGF may be regulated by extracellular inhibitors, because it is also produced in avascular tissues such as the cartilage. To seek the binding inhibitors against VEGF, we screened the chondrocyte cDNA library by a yeast two‐hybrid system by using VEGF165 as bait and identified connective tissue… 

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Connective Tissue Growth Factor Regulates Retinal Neovascularization through p53 Protein-dependent Transactivation of the Matrix Metalloproteinase (MMP)-2 Gene*

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Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-β

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Current evidence indicates that VEGF is essential for embryonic vasculogenesis and angiogenesis, and both therapeuticAngiogenesis using recombinant V EGF or VEGFs gene transfer and inhibition of VEGf-mediated pathological angiogenic are being pursued.
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