Connective tissue growth factor and regulation of the mesangial cell cycle: role in cellular hypertrophy.

@article{AbdelWahab2002ConnectiveTG,
  title={Connective tissue growth factor and regulation of the mesangial cell cycle: role in cellular hypertrophy.},
  author={Nadia Abdel-Wahab and Benjamin S. Weston and Terry P Roberts and Roger Maxwell Mason},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2002},
  volume={13 10},
  pages={
          2437-45
        }
}
Connective tissue growth factor (CTGF) is now considered to be one of the important driver molecules for the pathogenesis of diabetic nephropathy (DN) and possibly many other fibrotic disorders. However, the molecular mechanisms by which CTGF functions remain to be established. In an attempt to define these mechanisms, this study was designed to investigate whether CTGF has any effect on the cell cycle of human mesangial cells (HMC), which are known to undergo hypertrophy in DN. This report… CONTINUE READING

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