Connective tissue growth factor and its regulation in the peritoneal cavity of peritoneal dialysis patients.

@article{Zarrinkalam2003ConnectiveTG,
  title={Connective tissue growth factor and its regulation in the peritoneal cavity of peritoneal dialysis patients.},
  author={Krystyna H Zarrinkalam and Jodie M Stanley and Julia L Gray and N. A. Oliver and Randall James Faull},
  journal={Kidney international},
  year={2003},
  volume={64 1},
  pages={331-8}
}
BACKGROUND Connective tissue growth factor (CTGF) is a fibrogenic cytokine that is highly expressed in wound healing and fibrotic lesions. The role of transforming growth factor-beta (TGF-beta) in fibrosis is well documented, and the emerging understanding that its fibrogenic actions are mediated through CTGF has provided an attractive target molecule for the modulation of matrix overproduction in fibrotic disease. The involvement of CTGF in the pathogenesis of peritoneal membrane fibrosis in… CONTINUE READING

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