Connective tissue growth factor (CTGF/CCN2) is a downstream mediator for TGF-beta1-induced extracellular matrix production in osteoblasts.

@article{Arnott2007ConnectiveTG,
  title={Connective tissue growth factor (CTGF/CCN2) is a downstream mediator for TGF-beta1-induced extracellular matrix production in osteoblasts.},
  author={John A. Arnott and Edem Nuglozeh and Mario C. Rico and Israel Arango-Hisijara and Paul R. Odgren and Fayez F. Safadi and Steven N. Popoff},
  journal={Journal of cellular physiology},
  year={2007},
  volume={210 3},
  pages={843-52}
}
Connective tissue growth factor (CTGF/CCN2) is a cysteine-rich, extracellular matrix (ECM) protein that acts as an anabolic growth factor to regulate osteoblast differentiation and function. Recent studies have identified CTGF as a downstream effector of transforming growth factor-beta1 (TGF-beta1) for certain functions in specific cell types. In this study, we examined the role of CTGF as a downstream mediator of TGF-beta1-induced ECM production and cell growth in osteoblasts. Using primary… CONTINUE READING
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