Connective tissue growth factor (CTGF/CCN2) negatively regulates BMP-2 induced osteoblast differentiation and signaling.

@article{Mundy2014ConnectiveTG,
  title={Connective tissue growth factor (CTGF/CCN2) negatively regulates BMP-2 induced osteoblast differentiation and signaling.},
  author={Christina Mundy and Maureen Gannon and Steven N. Popoff},
  journal={Journal of cellular physiology},
  year={2014},
  volume={229 5},
  pages={672-81}
}
Connective tissue growth factor (CTGF/CCN2) and bone morphogenetic protein (BMP)-2 are both produced and secreted by osteoblasts. Both proteins have been shown to have independent effects in regulating osteoblast proliferation, maturation and mineralization. However, how these two proteins interact during osteoblast differentiation remains unknown. In this study, we utilized two cell culture model systems, osteoblasts derived from CTGF knockout (KO) mice and osteoblasts infected with an… CONTINUE READING
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Recombinant bone morphogenetic protein-2 accelerates bone cell differentiation and stimulates BMP-2 mRNA expression and BMP-2 promoter activity in primary fetal rat calvarial osteoblast cultures

  • S. E. Harris, J. Q. Feng, +4 authors G. R. Mundy
  • 1995
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