Connective tissue growth factor: a novel regulator of mucosal repair and fibrosis in inflammatory bowel disease?

@article{Dammeier1998ConnectiveTG,
  title={Connective tissue growth factor: a novel regulator of mucosal repair and fibrosis in inflammatory bowel disease?},
  author={Johanna Dammeier and Maria A Brauchle and Werner Falk and Gary R. Grotendorst and Sabine Werner},
  journal={The international journal of biochemistry & cell biology},
  year={1998},
  volume={30 8},
  pages={909-22}
}
Inflammatory bowel disease (IBD) is a multifactorial disorder which is characterized by massive damage of the epithelium and the underlying mesenchyme of the intestine. Due to the potent effect of connective tissue growth factor (CTGF) on fibroblast proliferation and connective tissue deposition we speculated about a possible role of this mitogen in IBD. Here we demonstrate a strikingly increased expression of CTGF mRNA in surgical specimens of patients suffering from two forms of IBD, Crohn's… CONTINUE READING
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