Connective tissue growth factor: a new and important player in the pathogenesis of fibrosis.

@article{Leask2002ConnectiveTG,
  title={Connective tissue growth factor: a new and important player in the pathogenesis of fibrosis.},
  author={Andrew Leask and Alan G. Holmes and David J. Abraham},
  journal={Current rheumatology reports},
  year={2002},
  volume={4 2},
  pages={136-42}
}
Connective tissue fibrosis is the final common pathogenic process for almost all forms of chronic tissue injury. Whether caused by vascular dysfunction, inflammation, metabolic injury, trauma, or environmental agents, once initiated the fibrogenic process results in the progressive replacement of the normal tissue architecture with fibrotic lesions that eventually lead to organ compromise and failure. Fibrosis can be considered as a dysregulation in the normal tissue repair mechanism, resulting… CONTINUE READING

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