Connective tissue growth factor/IGF-binding protein-related protein-2 is a mediator in the induction of fibronectin by advanced glycosylation end-products in human dermal fibroblasts.

@article{Twigg2002ConnectiveTG,
  title={Connective tissue growth factor/IGF-binding protein-related protein-2 is a mediator in the induction of fibronectin by advanced glycosylation end-products in human dermal fibroblasts.},
  author={Stephen Morris Twigg and Alison H. Joly and Michelle Mingzi Chen and Junko Tsubaki and Ho-Seong Kim and Vivian Hwa and Y. L. Oh and Ron G. Rosenfeld},
  journal={Endocrinology},
  year={2002},
  volume={143 4},
  pages={1260-9}
}
Expansion of extracellular matrix with fibrosis occurs in many tissues, including skin, as part of the end-organ complications in diabetes. Advanced glycosylation end-products (AGEs) have been implicated as a pathogenic factor in diabetic tissue fibrosis. Connective tissue growth factor (CTGF), also known as IGF-binding protein-related protein-2, induces extracellular matrix. We have recently shown that CTGF mRNA and protein are up-regulated by AGE treatment of cultured human dermal fibroblasts… CONTINUE READING

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