Connections and Regulation of the Human Estrogen Receptor

@article{McDonnell2002ConnectionsAR,
  title={Connections and Regulation of the Human Estrogen Receptor},
  author={Donald P. McDonnell and John D. Norris},
  journal={Science},
  year={2002},
  volume={296},
  pages={1642 - 1644}
}
Estrogen regulates a plethora of functionally dissimilar processes in a broad range of tissues. Recent progress in the study of the molecular mechanism of action of estrogen(s) has revealed why different cells can respond to the same hormone in a different manner. Three of these findings are of particular importance: (i) There are two genetically and functionally distinct estrogen receptors that have distinct expression patterns in vivo; (ii) the positive and negative transcriptional activities… 
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