Connection of lipid peroxide oxidation with the sphingomyelin pathway in the development of Alzheimer's disease.

@article{Alessenko2004ConnectionOL,
  title={Connection of lipid peroxide oxidation with the sphingomyelin pathway in the development of Alzheimer's disease.},
  author={Alice Alessenko and Anna E Bugrova and L. B. Dudnik},
  journal={Biochemical Society transactions},
  year={2004},
  volume={32 Pt 1},
  pages={144-6}
}
Alzheimer's disease (AD) is characterized by progressive decline in cognition, memory and intellect. It has been hypothesized that amyloid-beta peptide (A-beta) may have a prominent role in neurodegeneration. Oxidative mechanisms have been implicated in this pathway. There is substantial evidence that inflammatory mechanisms, induced by tumour necrosis factor alpha (TNF-alpha), are also involved in AD. TNF-alpha activates receptors linked to multiple effector systems, including a sphingomyelin… CONTINUE READING