Connecting the pathology of posttraumatic stress and substance use disorders: Monoamines and neuropeptides

@article{Enman2014ConnectingTP,
  title={Connecting the pathology of posttraumatic stress and substance use disorders: Monoamines and neuropeptides},
  author={Nicole M. Enman and Yong Zhang and Ellen M. Unterwald},
  journal={Pharmacology Biochemistry and Behavior},
  year={2014},
  volume={117},
  pages={61-69}
}
Posttraumatic stress disorder (PTSD) co-occurs highly with substance use disorders (SUDs), yet the neurobiological basis for this comorbid relationship remains unclear. PTSD and SUDs result in similar pathological states including impulsive behavior, reward deficiency, and heightened stress sensitivity. Hence, PTSD and SUD may depend on overlapping dysfunctional neurocircuitry. Here we provide a short overview of the relationship between comorbid PTSD and SUD, as well as the potential role of… CONTINUE READING

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