Connecting the nucleolus to the cell cycle and human disease.

Abstract

Long known as the center of ribosome synthesis, the nucleolus is connected to cell cycle regulation in more subtle ways. One is a surveillance system that reacts promptly when rRNA synthesis or processing is impaired, halting cell cycle progression. Conversely, the nucleolus also acts as a first-responder to growth-related stress signals. Here we review… (More)
DOI: 10.1096/fj.14-254680

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