Connecting the Dots: From DNA Damage and Repair to Aging

@article{Pan2016ConnectingTD,
  title={Connecting the Dots: From DNA Damage and Repair to Aging},
  author={Mei-Ren Pan and Kaiyi Li and Shiaw-Yih Lin and Wen-Chun Hung},
  journal={International Journal of Molecular Sciences},
  year={2016},
  volume={17}
}
  • M. Pan, Kaiyi Li, W. Hung
  • Published 1 May 2016
  • Biology
  • International Journal of Molecular Sciences
Mammalian cells evolve a delicate system, the DNA damage response (DDR) pathway, to monitor genomic integrity and to prevent the damage from both endogenous end exogenous insults. Emerging evidence suggests that aberrant DDR and deficient DNA repair are strongly associated with cancer and aging. Our understanding of the core program of DDR has made tremendous progress in the past two decades. However, the long list of the molecules involved in the DDR and DNA repair continues to grow and the… 

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