Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium

@article{HyerHansen2007ConnectingER,
  title={Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium},
  author={Maria H\oyer-Hansen and Marja J{\"a}{\"a}ttel{\"a}},
  journal={Cell Death and Differentiation},
  year={2007},
  volume={14},
  pages={1576-1582}
}
Eukaryotic cells respond to the accumulation of unfolded proteins in the endoplasmic reticulum (ER) either by unfolded protein response that leads to an increase in the capacity of the ER to fold its client proteins or by apoptosis when the function of ER cannot be restored. Emerging data now indicate that ER stress is also a potent inducer of macroautophagy, a process whereby eukaryotic cells recycle their macromolecules and organelles. Depending on the context, autophagy counterbalances ER… CONTINUE READING
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