Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases.

@article{Duboc2013ConnectingDB,
  title={Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases.},
  author={Henri Duboc and Sylvie Rajca and Dominique P. Rainteau and David Benarous and M A Maubert and Elodie Quervain and Ginette Thomas and V{\'e}ronique Barbu and Lydie Humbert and Guillaume Despras and Chantal Bridonneau and Fabien Dumetz and J Grill and Jo{\"e}lle Masliah and Laurent Beaugerie and Jacques Cosnes and Olivier Chazouilleres and Raoul Poupon and Claude Wolf and Jean-Maurice Mallet and Philippe Langella and Germain Trugnan and Harry Sokol and Philippe Seksik},
  journal={Gut},
  year={2013},
  volume={62 4},
  pages={531-9}
}
OBJECTIVE Gut microbiota metabolises bile acids (BA). As dysbiosis has been reported in inflammatory bowel diseases (IBD), we aim to investigate the impact of IBD-associated dysbiosis on BA metabolism and its influence on the epithelial cell inflammation response. DESIGN Faecal and serum BA rates, expressed as a proportion of total BA, were assessed by high-performance liquid chromatography tandem mass spectrometry in colonic IBD patients (42) and healthy subjects (29). The faecal microbiota… CONTINUE READING
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