Connecting chromosomes, crisis, and cancer.

  title={Connecting chromosomes, crisis, and cancer.},
  author={R. S. Maser and R. DePinho},
  volume={297 5581},
  • R. S. Maser, R. DePinho
  • Published 2002
  • Biology, Medicine
  • Science
  • Cancer is a disease of impaired genome stability. The molecular forces that maintain genome integrity and sense altered chromosome structure are invariably subverted in cancer cells. Here, we explore the contrasting contributions of telomeres in the initiation and suppression of cancer and review the evidence supporting a role for telomere dysfunction as a mechanism driving the radical chromosomal aberrations that typify cancer genomes. Recent work suggests that passage of cells through crisis… CONTINUE READING
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